When diagnosed at an early stage, treatment can include the surgical removal of the tumour. If a large portion of the lung is also removed this has life-long consequences for a patient.
We are seeking to understand what conditions are necessary to grow new lung tissue so that a patient has a better quality of life.
Our researchers have developed an animal model of compensatory lung growth following surgery. This model mimics the compensatory lung growth that has been described to occur in human children, and rarely in adults.
Following the surgical removal of a complete left lung, the right lung undergoes rapid growth and reaches a similar weight and volume to that of two normal lungs by 21 days post-surgery.
We are monitoring the changes associated with compensatory growth using a combination of genetic, histological, functional and longitudinally using micro CT imaging.
Understanding the mechanisms of lung growth and its capacity in humans will open up transformational research programs that may allow us to cure chronic lung diseases that are currently seen as untreatable.
Dr Andrew Lucas, who is part of the investigating team will present at the L I F E meeting in August. He will discuss the variety of experimental approaches being developed by the International Lung Research Community to produce better lung transplants and grow new lung tissues. He will also discuss our research on compensatory lung growth following surgery.