Respiratory Cancers

International Lung Screen Trial

International lung screen trial

An early lung cancer in an ex-smoker detected on ultra-low dose CT

Worldwide screen for lung cancer

LungScreen WA is part of an international study aiming to understand the best way of choosing high-risk people for lung cancer screening as well as a way of following up with repeat CT scans.

The International lung screen trial (ILST) is a big international study aiming to recruit more than 4,000 participants, with 2000 coming from Australia, and 500 from Perth. Other centres in Australia are Brisbane (where the study is based), Sydney and Melbourne.

There are a number of sub-studies from ILST, including our own in WA examining the best way to recruit people into a lung cancer screening program.


LungScreen WA team     

A/Prof Fraser Brims, Co-Principle Investigator

Dr Annette McWilliams

Dr Annette McWilliams, Co-Principle Investigator



Dr Conor Murray

Dr Conor Murray, Research Fellow


Dr Dave Manners

Dr Dave Manners, Research Fellow

  • Jacqui Logan, ILST Study Manager for WA
  • Siobhan Dormer, Research Nurse
  • Dr Kuan P Lim, Research Fellow
  • Dr Ed Harris, Research Fellow


Recent Publications

  • Annette McWilliams, Fraser Brims, Nanda Horeweg, Harry de Koning, James Jet. Lung Cancer Screening (chapter 7). International Association for the Study of Lung Cancer, Thoracic Oncology Textbook, 2nd Edition, 2017.
  • Manners, D., Wong, P., Murray, C., Teh, J., Kwok, Y. J., de Klerk, N., . . . Brims, F. J. H. (2017). Correlation of ultra-low dose chest CT findings with physiologic measures of asbestosis. EUROPEAN RADIOLOGY, 27(8), 3485-3490. doi:10.1007/s00330-016-4722-7
  • Brims, F. J. H. (2017). Integrated care for resected early stage lung cancer: innovations and exploring patient needs. BMJ Open Respiratory Research, 4, e000175. doi:10.1136/bmjresp-2016-000175
  • Weber, M., Yap, S., Goldsbury, D., Manners, D., Tammemagi, M., Marshall, H., . . . Canfell, K. (2017). Identifying high risk individuals for targeted lung cancer screening: Independent validation of the PLCO m2012 risk prediction tool. International Journal of Cancer, 141(2), 242-253. doi:10.1002/ijc.30673
  • Murray, C. P., Wong, P. M., Teh, J., de Klerk, N., Rosenow, T., Alfonso, H., . . . Brims, F. J. H. (2016). Ultra low dose CT screen-detected non-malignant incidental findings in the Western Australian Asbestos Review Programme. Respirology, 21(8), 1419-1424. doi:10.1111/resp.12826
  • Manners, D., Hui, J., Hunter, M., James, A., Knuiman, M. W., McWilliams, A., . . . Brims, F. J. H. (2016). Estimating eligibility for lung cancer screening in an Australian cohort, including the effect of spirometry. Medical Journal of Australia, 204(11), 406.e1-406.e6. doi:10.5694/mja16.00043
  • Manners, D., Emery, J., Brims, F. J., & Pettigrew, S. (2016). Lung cancer screening – Practical challenges of confining participation to those who might benefit. Australian and New Zealand Journal of Public Health, 40(3), 205-206. doi:10.1111/1753-6405.12516
  • Brims, F., McWilliams, A., & Fong, K. (2016). Lung cancer screening in Australia: Progress or procrastination?: There is progress internationally with lung cancer screening but far slower headway in Australia. Medical Journal of Australia, 204(1), 4-4.e1. doi:10.5694/mja15.01109
  • Manners, D., Emery, J., Brims, F., & Pettigrew, S. F. (2016). Lung Cancer Screening – Policy challenges of confining participation to those that might benefit. Australian and New Zealand Journal of Public Health, 40(3), 205-206. doi:10.1111/1753-6405.12516
  • Brims, F. J. H., Murray, C. P., De Klerk, N., Alfonso, H., Reid, A., Manners, D., . . . Musk, A. W. (2015). Ultra-low-dose chest computer tomography screening of an asbestos-exposed population in Western Australia. American Journal of Respiratory and Critical Care Medicine, 191(1), 113-116.
  • Brims, F., Musk, B., Reid, A., Pang, S. C., Franklin, P., Peters, S., & De Klerk, N. (2015). Presence of pleural plaques and/or asbestosis and the risk of lung cancer in a Crocidolite asbestos exposed population from Western Australia. In Journal of Thoracic Oncology Vol. 10 (pp. S613).
  • McWilliams A, Tammemagi M, Mayo JR, Lam S, Roberts H, Liu G et al. Malignancy risk of pulmonary nodules detected on first screening CT. NEJM, 2013; 369:910-919.
  • Cressman S, Lam S, Tammemagi M, Evans W, Leighl N, Regier D, Bolbocean C, Shepherd F, Tsao MS, Manos D, Liu G, Atkar-Khattra S, Cromwell I, Johnson M, Mayo J, McWilliams A, Couture C, English J, Goffin J, Hwang D, Puksa S, Roberts H, Tremblay A, MacEachern P, Burrowes P, Bhatia R, Finley R, Goss G, Nicholas G, Seely J, Sekhon H, Yee J, Amjadi K, Cutz JC, Ionescu D, Yasufuku K, Martel S, Soghrati K, Sin D, Tan W, Urbanski S, Xu Z, Peacock S. On behalf of the Pan-Canadian Early Detection of Lung Cancer Study Team. Resource Utilisation and Costs during the Initial Years of Lung Cancer Screening with Computed Tomography In Canada. JTO, 2014;9(10):1449-1458.
  • McWilliams A, Beigi P, Srinidhi A, Lam S, MacAulay C. Sex and Smoking Status Effects on the Early Detection of Early Lung Cancer in High-Risk Smokers using an Electronic Nose. IEEE Transactions on Biomedical Engineering, 2015;62(8):2044-2054. DOI: 10.1109/TBME.2015.2409092
  • McWilliams A. Does AQuIRE challenge the role of navigational bronchoscopy for peripheral pulmonary lesions? Ann Tranl Med, 2016;4(20):406.

International Lung Screen Trial was last modified: January 23rd, 2018 by Sarah Cermak

International Lung Screen Trial was last modified: January 23rd, 2018 by Sarah Cermak